Botox vs Dysport vs Xeomin: Daxxify & Letybo
Compare the five wrinkle relaxers offered at Beauty Medica, including their approved uses, formulation differences, and what matters for a natural-looking result.

Quick takeaways
- Each product has its own formulation and approved treatment areas.
- Your previous response and the movement you want to keep help guide the choice.
Which wrinkle relaxer is right for you?
Botox Cosmetic, Dysport, Xeomin, Daxxify, and Letybo all reduce selected muscle movement to soften facial lines. Their formulations and approved uses differ. Elena chooses among them after watching your expressions and hearing what you want to change.
For a local treatment assessment, start with neuromodulators in Boca Raton. This guide helps you understand the comparison before your visit.
Compare the five products
The table covers U.S. cosmetic labeling. It does not list every medical use. A clinician may recommend an approved product for an area outside its label and should explain that decision clearly.
| Product | Cosmetic areas in its U.S. label | A distinction to discuss |
|---|---|---|
| Botox Cosmetic | Frown lines, crow’s-feet, forehead lines, and platysma bands | A familiar treatment history can help Elena plan future visits. |
| Dysport | Moderate to severe frown lines in adults younger than 65 | Its formula may contain traces of cow’s milk protein. A true milk-protein allergy matters. |
| Xeomin | Upper facial lines, including the forehead, frown lines, and crow’s-feet | It contains active neurotoxin without accessory proteins. That alone does not establish a better result. |
| Daxxify | Moderate to severe frown lines in adults | Its peptide-containing formulation and duration evidence may interest patients thinking about maintenance. |
| Letybo | Moderate to severe frown lines in adults | It offers another formulation with its own clinical evidence and product-specific dosing. |
The prescribing information for each product is linked in Sources below. Forehead treatment with Botox Cosmetic is planned with glabellar treatment according to its label. Product selection still requires a personal examination.
Start with the expression, then the brand
A line that appears when you frown is different from a crease you see with your face fully relaxed. Wrinkle relaxers reduce muscle pull. A deeply etched line may also need attention to the skin itself.
Elena watches the relationship between your forehead and brows. Some people use forehead movement to help hold their brows up; softening it too much can feel heavy. Around the eyes, she considers the way your smile moves.
Tell her whether you want a subtle softening or a stronger reduction in movement. If you have had a result you liked, that experience is valuable. If you felt too still or noticed an unwanted change, describe it in your own words.
Skin-quality planning may be more useful when texture is the main concern. Filler planning addresses selected volume and support changes. These choices answer different questions.
Why units cannot be compared
Each manufacturer measures potency using its own preparation and assay. A unit from one product cannot be compared with or converted into a unit of another. Even matching numbers on two labels do not make the products equivalent.
Your dose is a clinical decision for the product chosen. An online conversion chart cannot tell you how much treatment your face needs.
Will one last longer?
Timing claims come from different studies, with different patients and definitions of response. They are useful context, but they do not create a reliable five-brand ranking.
Daxxify’s pivotal frown-line trials reported a median of about 24 weeks of none-or-mild severity by combined investigator and patient assessment. That finding applies to those trials and that area. It does not promise six months for everyone or establish the same duration elsewhere on the face. The Daxxify consultation page explains how to discuss it with Elena.
For every brand, follow-up depends on the product and your response. A longer-lasting effect can be convenient, but it also makes careful planning worthwhile. Once given, a wrinkle relaxer cannot simply be switched off.
Does the formulation matter?
It can, particularly when there is a relevant allergy or previous reaction. Dysport may contain cow’s milk protein; that allergy is different from lactose intolerance. Xeomin is made without accessory proteins. Daxxify uses a peptide excipient, while other products use different stabilizers.
These distinctions should be discussed against the full label. Describing one formula as universally cleaner or safer goes beyond what the comparison can establish.
What to bring to your visit
Bring any treatment record you already have. Useful details include the product used and when the effects wore off. Photographs can help explain a result you liked, although they cannot replace an examination.
You can also ask:
- Which product fits the area I want to treat, and why?
- How much movement are we trying to keep?
- When should I expect to review the result?
- Who should I contact if something feels wrong?
You do not need to arrive with a brand selected. Meet Elena Gorbunova, PA-C and learn about the medical experience behind her approach.
Recovery and important risks
Temporary tenderness, redness, swelling, or bruising can occur. Headache, eyelid or brow drooping, and unwanted weakness are possible. Each product’s label lists its contraindications and potential side effects.
All botulinum toxin products carry a boxed warning about effects spreading beyond the treated area. Trouble swallowing, speaking, or breathing needs immediate medical attention. Before treatment, discuss medicines and medical conditions, including neuromuscular conditions, pregnancy or breastfeeding, prior reactions, and any infection near the planned treatment site.
A proposed use outside a product’s approved areas is an off-label decision. Elena should explain the reason, evidence, and alternatives before you agree.
Put the comparison into a personal plan
The most useful next step is seeing how these differences apply to your face. Explore wrinkle-relaxer treatment at Beauty Medica or bring your questions directly to Elena.
Sources
- DailyMed: Botox Cosmetic prescribing information
- DailyMed: Dysport prescribing information
- DailyMed: Xeomin prescribing information
- DailyMed: Daxxify prescribing information
- DailyMed: Letybo prescribing information
- Carruthers et al. DaxibotulinumtoxinA for glabellar lines: SAKURA 1 and SAKURA 2. Plastic and Reconstructive Surgery. 2020.
About the author
- Beauty Medica Editorial TeamPatient Education & ResearchThe Beauty Medica Editorial Team develops patient-friendly, source-based guidance on treatment planning, safety, skin quality, injectables, and realistic aesthetic decision-making. Clinical review is credited separately when it has been completed.


